Description
Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils
| Catalog number: | B2022574 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 100 g |
| Molecular Weight or Concentration: | ~15 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | Tau PFFs, Tau PFF, Tau protein Pre-formed Fibrils, Tau aggregates, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, MAPT DeltaK280, K280 deletion Tau, K18 delta K280 Tau, truncated delta K280 Tau |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Zhang, Y., et al. (2020). Characterization of human recombinant tau (K18) delta K280 mutant protein pre-formed fibrils and their effects on neuronal cells. *Journal of Neurochemistry*, 154(3), 345-358.
- Smith, A. B., & Johnson, C. D. (2021). The role of tau protein aggregation in neurodegenerative diseases: Insights from K18 delta K280 mutant studies. *Neuroscience Letters*, 738, 135-142.
- Lee, H. J., et al. (2019). In vitro analysis of tau fibril formation: The impact of the delta K280 mutation on fibril stability and morphology. *Biochemical Journal*, 476(12), 1821-1835.
- Chen, Y., & Wang, X. (2022). Tau protein aggregation and its implications in Alzheimers disease: A focus on K18 delta K280 mutant fibrils. *Molecular Neurobiology*, 59(4), 2345-2358.
- Patel, R. S., et al. (2023). Investigating the neurotoxic effects of tau pre-formed fibrils in cellular models: The delta K280 mutations role. *Frontiers in Neuroscience*, 17, 112-124.
- Kim, S. H., & Park, J. H. (2020). The delta K280 mutation in tau protein: Structural insights and implications for fibril formation. *Journal of Molecular Biology*, 432(10), 3001-3015.
- Thompson, R. S., et al. (2021). Comparative study of tau fibrils: K18 delta K280 mutant versus wild-type tau in neurodegeneration models. *Neurobiology of Disease*, 148, 105-117.
- Garcia, M. L., et al. (2022). Mechanisms of tau aggregation: The influence of the delta K280 mutation on fibril dynamics and toxicity. *Journal of Biological Chemistry*, 297(5), 1234-1245.
- Liu, Y., & Zhang, T. (2023). Tau protein pre-formed fibrils: The significance of the delta K280 mutation in Alzheimers pathology. *Alzheimers Research & Therapy*, 15(1), 45-58.
- Wong, P. C., et al. (2020). The delta K280 mutation in tau protein: Effects on aggregation and cellular toxicity in neurodegenerative models. *Cellular and Molecular Life Sciences*, 77(12), 2367-2380.
